CD105/Endoglin Antibody (Center E395)

CD105/Endoglin Antibody (Center E395)is available at Gentaur for Next week Delivery.

Description: Endoglin (ENG, CD105) is an auxiliary receptor for the TGF-β receptor complex, functioning in related signaling pathways. Endoglin is a transmembrane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and in endothelial and stromal cells. Upregulated endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos. Mutations in endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure. The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer.

Immunogen Sequence:This CD105 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-409 amino acids from the Central region of human CD105.

Target Alternative Name:ENG; END; Endoglin

Species Reactivities:Human, Mouse.

Tag Line:Polyclonal Antibody to detect CD105 in human and mouse samples.

Formulation:In PBS with 0.09% (W/V) sodium azide.

Purification: Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Application:Western blot, IHC, FACS.

Positive Control:Western blot: Mouse heart tissue lysate, IHC: mouse heart tissue, FACS: NCI-H292.

Application And Usages:WB: 1:1000, IHC: 1:10 – 1:50, FC: 1:10 – 1:50.

Handling:The antibody solution should be gently mixed before use.