ASK1/MAPKKK5 Antibody

ASK1/MAPKKK5 Antibodyis available at Gentaur for Next week Delivery.

Description: ASK1 (Apoptosis Signal-regulating Kinase 1) activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activate c-Jun N-terminal Kinase (JNK) and p38 MAP Kinase. ASK1 is activated by TNFR and Fas throμgh the interaction with members of the TRAF Family and the Fas-associated protein Daxx. Overexpression of ASK1 induces apoptosis. However, a catalytically inactive form of ASK1 has been shown to inhibit TNF-α induced apoptosis.

Immunogen Sequence:Synthetic peptide corresponding to residue surrounding amino acid 1359 of human ASK1

Target Alternative Name:MAP3K5, MEKK5, ASK-1 , MAPKKK5

Species Reactivities:Human

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Formulation:100 µg (0.2 mg/ml) immunoaffinity purified, rabbit anti-ASK1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% sodium azide.

Purification: Affinity purified

Application:Western blot, Immunofluorescence

Positive Control:/

Application And Usages:Western blot analysis (1-4 µg/ml). However, the optimal conditions should be determined individually. The immunoaffinity purified antibody detects the 155 kDa ASK1 protein in human SW1353 cell lysate by immunoblotting.

Handling:The antibody solution should be gently mixed before use.