Anti-Toxin B (Bezlotoxumab), Human IgG1 Antibody

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SKU:
A2220-100
$460
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Description

Anti-Toxin B (Bezlotoxumab), Human IgG1 Antibodyis available at Gentaur for Next week Delivery.

Description: The research-grade biosimilar is a human monoclonal antibody that targets Clostridium difficile toxin B. Toxin B (TcdB) is a glucosyltransferase protein that glucosylates small GTPases such as Rho, Rac, and Cdc42 in the target cells. The toxin is known to disrupt the actin cytoskeleton of the cells by causing condensation of the actin, blebbing of the membrane, which eventually leads to apoptosis and cell death. The antibody binds to the two epitopes on the N-terminal of the Toxin B CROP domain via its two Fab regions, thus partially blocking carbohydrate-binding pockets and prevents the binding of the toxin to the host cells. The original monoclonal antibody was approved by the FDA to treat adult patients who are either receiving antibacterial treatment for Clostridium difficile infection (CDI) or are at a high risk of getting re-infected with CDI

Immunogen Sequence:Clostridium difficile Toxin B

Target Alternative Name:MBL-CDB1, MK-6072, CDB-1, MDX-1388, MK-3415A, tcdB, glycosylating toxin TcdB

Species Reactivities:Clostridium difficile

Tag Line:The biosimilar is a human monoclonal antibody that targets and inhibits the binding of Clostridium difficile toxin B to mammalian host cells

Formulation:In PBS, pH 7.5

Purification: Protein A purified

Application:/

Positive Control:/

Application And Usages:/

Handling:The antibody solution should be gently mixed before use.

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Additional Information

Size:
100 µg
Antibody Target:
Toxin B
Category:
Biosimilars
Host:
Recombinant
Antibody Type:
Monoclonal
Isotype:
IgG1, kappa
Accession Number:
P18177/DB13140
Concentration:
1 mg/ml
Appearance:
Colorless liquid
Form:
Liquid
Storage Condition:
-80ºC
Shipping Condition:
Gel Pack
Shelf Life:
12 months
Country of Animal Origin:
USA
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans.
Western Blot Verified:
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Immunocytochemistry Verified:
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Immunofluorescence Verified:
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Immunoprecipitation Verified:
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FACS Verified:
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ELISA Verified:
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ChIP Verified:
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Dot Blot Verified:
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Flow Cytometry Verified:
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