Anti-Pyruvate Dehydrogenase E2 Polyclonal Antibody

Anti-Pyruvate Dehydrogenase E2 Polyclonal Antibodyis available at Gentaur for Next week Delivery.

Description: The multi-component pyruvate dehydrogenase complex is a group of enzymes in the inner mitochondrial membrane that catalyzes the conversion of pyruvate into acetyl coenzyme A and links glycolysis to the Krebs cycle in cellular respiration. The E2 component, also known as dihydrolipoamide acetyltransferase, accepts the acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to conezyme A. The E2 component is an antigen for antimitochondrial antibodies, which are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis. Disruptions in the E2 gene can cause a deficiency in E2 protein, which can in turn cause primary lactic acidosis in infancy and early childhood.

Immunogen Sequence:Recombinant fusion protein of human pyruvate dehydrogenase E2

Target Alternative Name:Dihydrolipoamide S-Acetyltransferase; PDC-E2; PDCE2; DLTA; PBC; E2; DLAT

Species Reactivities:Mouse Rat Human

Tag Line:Part of the pyruvate dehydrogenase complex that catalyzes the conversion of pyruvate to acetyl CoA

Formulation:In PBS with 0.02% sodium azide, 50% glycerol, pH 7.3

Purification: Affinity purification

Application:Immunofluorescence (IF) Immunohistochemistry (IHC) Western Blotting

Positive Control:/

Application And Usages:/

Handling:The antibody solution should be gently mixed before use.