Anti-PD-L1 Monoclonal Antibody (Clone: ABM5F25)

Anti-PD-L1 Monoclonal Antibody (Clone: ABM5F25)is available at Gentaur for Next week Delivery.

Description: PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belongs to the B7 superfamily that inhibits immune responses through its receptor, PD-1 and PD-L1 play a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells and induce T cell anergy. Aberrant expression and dysregulation of CD274 have been reported during bacterial infection, inflammation and in numerous autoimmune diseases.

Immunogen Sequence:A partial length recombinant protein of PD-L1 (amino acid 13-224) was used as the immunogen

Target Alternative Name:CD274,B7H1,PDCD1L1,PDCD1LG1,PDL1

Species Reactivities:Human

Tag Line:Monoclonal antibody for the detection of PD-L1 in human cells and tissues

Formulation:0.5 mg/ml in Supplied in PBS containing 0.05% BSA and 0.05% Sodium azide.

Purification: Protein G Chromatography

Application:WB, FACS, IHC

Positive Control:/

Application And Usages:WB: 2-4 mg/ml; FACS: 0.5-1 mg/106 cells; IHC: 5-10 mg/ml

Handling:The antibody solution should be gently mixed before use