Anti-PD-L1 Antibody (IHC411)

Anti-PD-L1 Antibody (IHC411)is available at Gentaur for Next week Delivery.

Description: Programmed Death-Ligand 1 (PD-L1), also known as CD274 or B7 Homolog 1 (B7-H1), is a transmembrane protein involved in suppressing the immune system and rendering tumor cells resistant to CD8+ T cell-mediated lysis through binding of the Programmed Death-1 (PD-1) receptor. Overexpression of PD-L1 may allow cancer cells to evade the actions of the host immune system. In renal cell carcinoma, upregulation of PD-L1 has been linked to increased tumor aggressiveness and risk of death, and, in ovarian cancer, higher expression of this protein lead to significantly poorer prognosis. PD-L1 has also been linked to systemic lupus erythematosus and cutaneous melanoma. When considered in adjunct with CD8+ tumor-infiltrating lymphocyte density, expression levels of PD-L1 may be a useful predictor of multiple cancer types, including stage III non-small cell lung cancer, hormone receptor negative breast cancer, and sentinel lymph node melanoma.

Immunogen Sequence:PD-L1

Target Alternative Name:Programmed cell death 1 ligand 1, PD-L1, PDCD1 ligand 1, programmed death ligand 1, B7 homolog 1, B7-H1, CD274

Species Reactivities:Human

Tag Line:Monoclonal Antibody to detect PD-L1 in human samples

Formulation:Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide

Purification: Protein A/G purification

Application:IHC

Positive Control:IHC: Lung

Application And Usages:IHC: 1:100 - 1:200

Handling:The antibody solution should be gently mixed before use