Anti-PAD4 Polyclonal Antibody

Anti-PAD4 Polyclonal Antibodyis available at Gentaur for Next week Delivery.

Description: Protein arginine deiminases (PADs) are a family of guanidine-modifying enzymes that catalyze the post-translational modification of target proteins by converting arginine to citrulline. Excessive citrullination of proteins may result in disease states. PAD4 (also known as PADI5) is expressed in neutrophils and in a variety of tissues. PAD4 is known to citrullinate histones, which initiates chromatin decondensation in neutrophils and the subsequent release of neutrophil extracellular traps (NETs), which leads to a lytic form of cell death known as NETosis. The presence of serum PAD4 autoantibodies has been associated with rheumatoid arthritis.

Immunogen Sequence:Recombinant full length protein of human PAD4

Target Alternative Name:Peptidyl Arginine Deiminase 4; PDI5; Peptidyl Arginine Deiminase, Type IV; Peptidyl Arginine Deiminase, Type V; Protein-Arginine Deiminase Type IV; Protein-Arginine Deiminase Type-4; EC 3.5.3.15; HL-60 PAD; PADI5; PDI4; PAD; Peptidylarginine Deiminase IV; PADI-H Protein; PADI4

Species Reactivities:Human Rat

Tag Line:Protein arginine deiminase associated with rheumatoid arthritis

Formulation:in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide

Purification: Immunogen affinity chromatography

Application:Immunofluorescence (IF) Immunohistochemistry (IHC) Western Blotting

Positive Control:/

Application And Usages:/

Handling:The antibody solution should be gently mixed before use.