Anti-NFkB p65 Rabbit Monoclonal Antibody

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SKU:
A1591-50
£208.54
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Description

Anti-NFkB p65 Rabbit Monoclonal Antibodyis available at Gentaur for Next week Delivery.

Description: NFkB was identified as a sequence specific transcriptional activator that binds to the intronic enhancer of kappa light chain gene in B lymphocytes. NFkB is a heterodimer that consists of a 50 kDa DNA binding subunit (p50) and a 65 kDa transactivation subunit (p65/RelA). Both of these subunits exhibit sequence homology to the protooncogene c-Rel. The p50/p65 heterodimer remains in the cytosol in an inactive form as a complex with its inhibitor, IkB. Upon stimulation of cells by a wide variety of stimuli such as lipopolysaccharide (LPS), pro-inflammatory cytokines, and viral infection. IkB is phosphorylated and degraded by proteosome. The active NFkB heterodimer is translocated into the nucleus and induces gene expression.

Immunogen Sequence:A peptide corresponding to the area near the C-terminus of human transcription factor p65 (NFkB p65 subunit)

Target Alternative Name:RELA, NFKB3, mgC131774

Species Reactivities:Human

Tag Line:Monoclonal antibody to detect endogenous levels of NF kappaB p65 in human samples

Formulation:In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

Purification: Affinity purified

Application:WB, IHC

Positive Control:WB: MCF-7 cell lysates, IHC: human breast cancer tissue

Application And Usages:WB: 1:500 - 1:1000, IHC: 1:500 -1:1500

Handling:The antibody solution should be gently mixed before use.

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Additional Information

Size:
50 µl
Antibody Target:
Transcription factor p65
Category:
Signal Transduction
Host:
Rabbit
Antibody Type:
Monoclonal
Isotype:
Rabbit IgG
Accession Number:
Q04206
Gene Id:
5970
Appearance:
Colorless liquid
Form:
Liquid
Storage Condition:
-20 °C
Shipping Condition:
gel pack
Shelf Life:
12 months
Country of Animal Origin:
USA
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans.
Western Blot Verified:
Verified
Immunocytochemistry Verified:
Verified
Immunofluorescence Verified:
Not Verified
Immunoprecipitation Verified:
Not Verified
FACS Verified:
Not Verified
ELISA Verified:
Not Verified
ChIP Verified:
Not Verified
Dot Blot Verified:
Not Verified
Flow Cytometry Verified:
Not Verified
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