Anti-NFkB p65 Rabbit Monoclonal Antibody

Anti-NFkB p65 Rabbit Monoclonal Antibodyis available at Gentaur for Next week Delivery.

Description: NFkB was identified as a sequence specific transcriptional activator that binds to the intronic enhancer of kappa light chain gene in B lymphocytes. NFkB is a heterodimer that consists of a 50 kDa DNA binding subunit (p50) and a 65 kDa transactivation subunit (p65/RelA). Both of these subunits exhibit sequence homology to the protooncogene c-Rel. The p50/p65 heterodimer remains in the cytosol in an inactive form as a complex with its inhibitor, IkB. Upon stimulation of cells by a wide variety of stimuli such as lipopolysaccharide (LPS), pro-inflammatory cytokines, and viral infection. IkB is phosphorylated and degraded by proteosome. The active NFkB heterodimer is translocated into the nucleus and induces gene expression.

Immunogen Sequence:A peptide corresponding to the area near the C-terminus of human transcription factor p65 (NFkB p65 subunit)

Target Alternative Name:RELA, NFKB3, mgC131774

Species Reactivities:Human

Tag Line:Monoclonal antibody to detect endogenous levels of NF kappaB p65 in human samples

Formulation:In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

Purification: Affinity purified

Application:WB, IHC

Positive Control:WB: MCF-7 cell lysates, IHC: human breast cancer tissue

Application And Usages:WB: 1:500 - 1:1000, IHC: 1:500 -1:1500

Handling:The antibody solution should be gently mixed before use.