Anti-MSLN (Anetumab), Human IgG1 Antibody

Anti-MSLN (Anetumab), Human IgG1 Antibodyis available at Gentaur for Next week Delivery.

Description: The research-grade biosimilar is a recombinant antibody to Anetumab without the drug conjugation. The original antibody-drug conjugate (Anetumab Ravtansine) consists of an anti-mesothelin (MSLN) human IgG1 antibody conjugated to DM4, an anti-tumor chemical derivative of maytansine via a disulfide-containing cleavable sulfo-SPDB linker. Upon interaction and internalization by MSLN expressing tumor cells, the DM4 is detached from the antibody due to proteolytic cleavage. The DM4 then inhibits polymerization of the tubulin and disrupts the microtubule assembly, thereby leading to cell cycle arrest and apoptosis. The original antibody-drug conjugate is used as an investigational agent to treat pancreatic, ovarian cancer, and advanced or recurrent mesothelioma.

Immunogen Sequence:Human MSLN

Target Alternative Name:MPF, SMRP, MSLN, Mesothelin, CAK1, CAK1 Antigen

Species Reactivities:Human

Tag Line:The biosimilar is a human IgG1 antibody that targets Mesothelin (MSLN)

Formulation:In PBS, pH 7.5

Purification: Protein A purified

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Handling:The antibody solution should be gently mixed before use.