Anti-COX-2 Rabbit Monoclonal Antibody (RM348)

Anti-COX-2 Rabbit Monoclonal Antibody (RM348)is available at Gentaur for Next week Delivery.

Description: COX proteins are membrane-associated heme proteins that have cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (Nonsteroidal anti-inflammatory drμgs) such as aspirin. Prostaglandins (PGs) formed by the enzymatic activity of COX-1 are primarily involved in the regulation of homeostatic functions throμghout the body, whereas PGs formed by COX-2 primarily mediate pain, fever, and inflammation. COX-1 is constitutively expressed, with particularly high expression in gastrointestinal tissues. COX-2 is induced by cytokines and mitogens and is likely to play a role in inflammatory diseases such as rheumatoid arthritis. In rodents and humans, COX-3 encodes proteins with completely different amino acid sequences than COX-1 or COX-2 and without COX activity. It has been suggested COX-3 as the key to unlocking the mystery of the mechanism of action of acetaminophen.

Immunogen Sequence:A peptide corresponding to the C-terminus of human COX-2.

Target Alternative Name:/

Species Reactivities:Human

Tag Line:Affinity purified Rabbit monoclonal to COX-2

Formulation:50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

Purification: Protein A affinity purified from an animal origin–free culture supernatant

Application:IHC: 1:500-1:1000, Western Blot: 1:1000-1:20000

Positive Control:/

Application And Usages:IHC: 1:500-1:1000, Western Blot: 1:1000-1:20000

Handling:The antibody solution should be gently mixed before use.