Anti-COX-2 Rabbit Monoclonal Antibody (RM348)

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SKU:
A1853-50
€250
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Description

Anti-COX-2 Rabbit Monoclonal Antibody (RM348)is available at Gentaur for Next week Delivery.

Description: COX proteins are membrane-associated heme proteins that have cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (Nonsteroidal anti-inflammatory drμgs) such as aspirin. Prostaglandins (PGs) formed by the enzymatic activity of COX-1 are primarily involved in the regulation of homeostatic functions throμghout the body, whereas PGs formed by COX-2 primarily mediate pain, fever, and inflammation. COX-1 is constitutively expressed, with particularly high expression in gastrointestinal tissues. COX-2 is induced by cytokines and mitogens and is likely to play a role in inflammatory diseases such as rheumatoid arthritis. In rodents and humans, COX-3 encodes proteins with completely different amino acid sequences than COX-1 or COX-2 and without COX activity. It has been suggested COX-3 as the key to unlocking the mystery of the mechanism of action of acetaminophen.

Immunogen Sequence:A peptide corresponding to the C-terminus of human COX-2.

Target Alternative Name:/

Species Reactivities:Human

Tag Line:Affinity purified Rabbit monoclonal to COX-2

Formulation:50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

Purification: Protein A affinity purified from an animal origin–free culture supernatant

Application:IHC: 1:500-1:1000, Western Blot: 1:1000-1:20000

Positive Control:/

Application And Usages:IHC: 1:500-1:1000, Western Blot: 1:1000-1:20000

Handling:The antibody solution should be gently mixed before use.

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Additional Information

Size:
50 µl
Antibody Target:
COX-2
Category:
Primary antibody
Host:
Rabbit
Antibody Type:
Monoclonal
Isotype:
Rabbit IgG
Accession Number:
P35354
Gene Id:
5743
Appearance:
Liquid
Form:
Liquid
Storage Condition:
-20ºC
Shipping Condition:
Gel Pack
Shelf Life:
12 months
Country of Animal Origin:
USA
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans.
Western Blot Verified:
True
Immunocytochemistry Verified:
True
Immunofluorescence Verified:
False
Immunoprecipitation Verified:
False
FACS Verified:
False
ELISA Verified:
False
ChIP Verified:
False
Dot Blot Verified:
False
Flow Cytometry Verified:
False
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