Anti-Cathepsin S Antibody

Anti-Cathepsin S Antibodyis available at Gentaur for Next week Delivery.

Description: Cathepsin S (CTSS) is a lysosomal cysteine protease of the papain family and may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS is synthesized as inactive precursor of 331 amino acids consisting of a 15-aa signal peptide, a propeptide of 99 aa, and a mature polypeptide of 217 aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. The deduced amino acid sequence contains only one potential N-glycosylation site located in the propeptide. Compared with the abundant cathepsins B, L and H, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicate that cathepsin S generates amyloid beta-peptide from amyloidogenic fragments of amyloid precursor protein (APP) in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer’s disease and Down Syndrome.

Immunogen Sequence:A synthesized peptide derived from human CTSS

Target Alternative Name:Cathepsin S; CathepsinS; CATS_HUMAN; Ctss

Species Reactivities:Human, Mouse, Rat

Tag Line:Polyclonal antibody to detect endogenous levels of Cathepsin S in human samples

Formulation:In phosphate buffered saline , pH 7.4, 150mM, NaCl, 0.02% sodium azide and 50% glycerol.

Purification: Affinity purified

Application:WB, IHC

Positive Control:WB: HuvEc whole cell lysates, IHC: mouse kidney tissue

Application And Usages:WB 1:1000-3000, IHC 1:200

Handling:The antibody solution should be gently mixed before use.