Cathepsin S Antibody

Cathepsin S Antibodyis available at Gentaur for Next week Delivery.

Description: Cathepsin S (CTSS) is a lysosomal cysteine protease of the papain family and may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS is synthesized as inactive precursor of 331 amino acids consisting of a 15-aa signal peptide, a propeptide of 99 aa, and a mature polypeptide of 217 aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. The deduced amino acid sequence contains only one potential N-glycosylation site located in the propeptide. Compared with the abundant cathepsins B, L and H, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicate that cathepsin S generates amyloid beta-peptide from amyloidogenic fragments of amyloid precursor protein (APP) in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer’s disease and Down Syndrome.

Immunogen Sequence:Human Recombinant Cathepsin S, Cat # 7525

Target Alternative Name:CTSS

Species Reactivities:Human, Mouse

Tag Line:Polyclonal Antibody to detect Cathepsin S in human samples

Formulation:30 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol.

Purification: Affinity Purified Antibody

Application:Western blot

Positive Control:Western Blot: Jurkat cell lysate, mouse muscle lysate, recombinant protein

Application And Usages:Western blot: 1-4 µg

Handling:The antibody solution should be gently mixed before use.