Description
Anti-Cathepsin S Antibodyis available at Gentaur for Next week Delivery.
Description: Cathepsin S (CTSS) is a lysosomal cysteine protease of the papain family and may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS is synthesized as inactive precursor of 331 amino acids consisting of a 15-aa signal peptide, a propeptide of 99 aa, and a mature polypeptide of 217 aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. The deduced amino acid sequence contains only one potential N-glycosylation site located in the propeptide. Compared with the abundant cathepsins B, L and H, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicate that cathepsin S generates amyloid beta-peptide from amyloidogenic fragments of amyloid precursor protein (APP) in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer’s disease and Down Syndrome.
Immunogen Sequence:A synthesized peptide derived from human CTSS
Target Alternative Name:Cathepsin S; CathepsinS; CATS_HUMAN; Ctss
Species Reactivities:Human, Mouse, Rat
Tag Line:Polyclonal antibody to detect endogenous levels of Cathepsin S in human samples
Formulation:In phosphate buffered saline , pH 7.4, 150mM, NaCl, 0.02% sodium azide and 50% glycerol.
Purification: Affinity purified
Application:WB, IHC
Positive Control:WB: HuvEc whole cell lysates, IHC: mouse kidney tissue
Application And Usages:WB 1:1000-3000, IHC 1:200
Handling:The antibody solution should be gently mixed before use.
Additional Information
Size: |
100 µl |
Antibody Target: |
CTSS |
Category: |
Signal Transduction |
Host: |
Rabbit |
Antibody Type: |
Polyclonal |
Isotype: |
Rabbit IgG |
Accession Number: |
P25774 |
Gene Id: |
1520 |
Concentration: |
1 mg/ml |
Appearance: |
Colorless liquid |
Form: |
Liquid |
Storage Condition: |
-20°C |
Shipping Condition: |
gel pack |
Shelf Life: |
23 months |
Country of Animal Origin: |
USA |
Country of Manufacture: |
USA |
Usage: |
For Research Use Only! Not to be used in humans. |
Western Blot Verified: |
Verified |
Immunocytochemistry Verified: |
Verified |
Immunofluorescence Verified: |
Not Verified |
Immunoprecipitation Verified: |
Not Verified |
FACS Verified: |
Not Verified |
ELISA Verified: |
Not Verified |
ChIP Verified: |
Not Verified |
Dot Blot Verified: |
Not Verified |
Flow Cytometry Verified: |
Not Verified |