VEGF-D, human recombinant

VEGF-D, human recombinant is available at Gentaur for Next week delivery.

A protein involved in angiogenesis, lymphangiogenesis and endothelial cell growth and survival

Biomolecule/Target: VEGF-D

Alternates names: Vascular Endothelial Growth Factor-D, FIGF, c-Fos-induced growth factor

Synonyms: Vascular Endothelial Growth Factor-D, FIGF

Background Information: VEGF-D is most closely related to VEGF-C by virtue of the presence of N- and C-terminal extensions that are not found in other VEGF family members. In adult human tissues, VEGF-D mRNA is most abundant in heart, lung, skeletal muscle, colon, and small intestine. Analyses of VEGF-D receptor specificity revealed that VEGF-D is a ligand for both VEGF receptors (VEGFRs) VEGFR-2 (Flk1) and VEGFR-3 (Flt4) and can activate these receptors. However, VEGF-D does not bind to VEGFR-1. Expression of a truncated derivative of VEGF-D demonstrated that the receptor-binding capacities reside in the portion of the molecule that is most closely related in primary structure to other VEGF family members and that corresponds to the mature form of VEGF-C. In addition, VEGF-D is a mitogen for endothelial cells. Recombinant VEGF-D was expressed based on sequence from Genebank Accession# D89630, 20-354 aa.

Reconstitution Instructions: Reconstitute in dH₂O to a concentration of 0.1-1.0 mg/ml. The solution should be stored at -70°C.

NCBI Gene Symbol: FIGF

Gene ID: 2277

NCBI Accession: O43915