VEGF-B, human recombinant

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SKU:
4642-20
$183
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Description

VEGF-B, human recombinant is available at Gentaur for Next week delivery.

Involved in maintenance of newly formed blood vessels during pathological conditions

Biomolecule/Target: VEGF-B

Alternates names: Vascular Endothelial Growth Factor-B, VEGFB, VEGF-related factor

Synonyms: Vascular Endothelial Growth Factor-B, VEGFB

Background Information: VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial cells, regulates angiogenesis and Vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. VEGF-B is expressed in all tissues except the liver. It forms cell surfaced-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a “cysteine knot” like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. Recombinant human VEGF-B is a 38.0 kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.

Reconstitution Instructions: Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/ml. The solution should be stored at -70°C.

NCBI Gene Symbol: VEGFB

Gene ID: 7423

NCBI Accession: P49765

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Additional Information

Size:
20 μg
Adwords:
yes
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
E. coli
Purity by SDS-PAGE:
≥98%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
HPLC
Endotoxin Level:
<0.1 ng/μg
Activity (Specifications/test method):
N/A
Biological activity:
Per researcher’s feedback, the protein is biologically active as determined by the dose-dependent stimulation of the proliferation of human μmbilical vein endothelial cells (HUVEC) in the presence of human VEGF165. The expected ED₅₀ for this effect i
Results:
0.5-5 µg/ml
Molecular Weight:
19.63 kDa
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized protein
Handling:
Centrifuge the vial prior to opening.
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