VEGF-B, human recombinant

VEGF-B, human recombinant is available at Gentaur for Next week delivery.

Involved in maintenance of newly formed blood vessels during pathological conditions

Biomolecule/Target: VEGF-B

Alternates names: Vascular Endothelial Growth Factor-B, VEGFB, VEGF-related factor

Synonyms: Vascular Endothelial Growth Factor-B, VEGFB

Background Information: VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial cells, regulates angiogenesis and Vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. VEGF-B is expressed in all tissues except the liver. It forms cell surfaced-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a “cysteine knot” like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. Recombinant human VEGF-B is a 38.0 kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.

Reconstitution Instructions: Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/ml. The solution should be stored at -70°C.

NCBI Gene Symbol: VEGFB

Gene ID: 7423

NCBI Accession: P49765