UbcH5c, human recombinant (His-tag)

UbcH5c, human recombinant (His-tag) is available at Gentaur for Next week delivery.

An essential ubiquitin-conjugating enzyme

Biomolecule/Target:

Alternates names: UbcH5c, Ubiquitin conjugating enzyme H5c, Ubiquitin conjugating enzyme, Ubiquitin carrier protein D3, Ubiquitin-conjugating enzyme E2(17)KB 3, Ubiquitin-conjugating enzyme E2-17 kDa 3, Ubiquitin-protein ligase D3

Synonyms: UbcH5c, Ubiquitin conjugating enzyme H5c, Ubiquitin conjugating enzyme

Background Information: UbcH5c is highly homologous to the S. cerevisiae UbC4/5 family of E2 enzymes, demonstrated to be essential for degradation of regulatory and abnormal proteins. UbcH5c, together with UbcH5a and UbcH5b, are the most active class of E2 enzymes in cell extracts and are associated with regulation of a number of transcription factors including p53. The His-tagged version of this enzyme is not susceptible to self-ubiquitinylation, which can occur with GST-tagged versions. Typical enzyme concentration to support in vitro conjugation is 100 nM to 1 µM depending upon the conditions.

Reconstitution Instructions: N/A

NCBI Gene Symbol: UB2D3

Gene ID: 7323

NCBI Accession: P61077