TPA, Human Recombinant (Sf9)

TPA, Human Recombinant (Sf9) is available at Gentaur for Next week delivery.

Plays a role in cell migration and tissue remodeling.

Biomolecule/Target: TPA

Alternates names: Tissue-type plasminogen activator, EC 3.4.21.68, tPA, t-PA, t-plasminogen activator, TPA, T-PA, DKFZp686I03148, PLAT and tPA.

Synonyms: Tissue-type plasminogen activator, EC 3.4.21.68, tPA, t-PA, t-plasminogen activator, TPA, T-PA, DKFZp686I03148, PLAT and tPA.

Background Information: Tissue plasminogen activator (PLAT or tPA) is a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Plasminogen is synthesized as a single chain which is cleaved by PLAT into the two chain disulfide linked plasmin. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. tPA Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 545 amino acids (24-562 a.a) and having a molecular mass of 61.3 kDa (Molecular size on SDS-PAGE will appear at approximately 50-70 kDa). tPA is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

Reconstitution Instructions: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time and for long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).

NCBI Gene Symbol: PLAT

Gene ID:

NCBI Accession: P00750