TNF Receptor-Associated Protein 1 (TRAP1), Human Recombinant

TNF Receptor-Associated Protein 1 (TRAP1), Human Recombinant is available at Gentaur for Next week delivery.

Interacts with EXT2, EXT1 and Retinoblastoma protein

Biomolecule/Target:

Alternates names: HSP75, Mitochondrial HSP90, MtHSP90

Synonyms: HSP75, Mitochondrial HSP90, MtHSP90

Background Information: The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress. It includes cytoplasmic (Hsp90-alpha/beta), ER (Grp94) and mitochondrial (TRAP1) localized members. Hsp90 is structurally composed of an N-terminal ATP binding domain, a medial substrate-binding region, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones to stabilize a multitude of client proteins substrates. TRAP1 (aka Hsp75) was originally identified as a chaperone binding partner for retinoblastoma protein. TRAP1 was later found by immunofluorescence to be localized to the mitochondria. TRAP1 is significantly more active as an ATPase due in part to the lack of regulatory elements in the C-terminus, but retains the ability to dimerize. However, it does not form stable complexes with typical cochaperones of Hsp90 like p23 and HOP4. TRAP1 has been identified as a protective element for cell survival, and has been suggested as a target for anti-cancer therapeutics.

Reconstitution Instructions:

NCBI Gene Symbol: TRAP1

Gene ID: 10131

NCBI Accession: Q12931