Description
TLR4 / CD284, Human Recombinant is available at Gentaur for Next week delivery.
TLR family member which plays a fundamental role in pathogen recognition and activation of innate immunity
Biomolecule/Target:
Alternates names: ARMD10, CD284, TLR-4, TLR4, TOLL
Synonyms: ARMD10, CD284, TLR-4, TLR4, TOLL
Background Information: TLR4 is a member of Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR4 receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.
Reconstitution Instructions:
NCBI Gene Symbol: TLR4
Gene ID: 7099
NCBI Accession: O00206
Additional Information
Size: |
50 µg |
Adwords: |
False |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
N/A |
Gene Source: |
Human |
Recombinant: |
True |
Source: |
Insect Cells (sf9) |
Purity by SDS-PAGE: |
>95% |
Assay: |
SDS-PAGE. |
Activity (Specifications/test method): |
Measured by its binding ability in a functional ELISA. The concentration of human recombinant MD2 that produces 50% optimal binding response with immobilized human recombinant TLR4 at 2 μg/mL (100 μL/well) is approximately 0.5 μg/mL. |
Molecular Weight: |
70.5 kDa (C terminal 6x His tag) |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Appearance: |
Sterile Filtered colorless solution |
Handling: |
Centrifuge the vial prior to opening. |