TLR4 / CD284, Human Recombinant

TLR4 / CD284, Human Recombinant is available at Gentaur for Next week delivery.

TLR family member which plays a fundamental role in pathogen recognition and activation of innate immunity

Biomolecule/Target:

Alternates names: ARMD10, CD284, TLR-4, TLR4, TOLL

Synonyms: ARMD10, CD284, TLR-4, TLR4, TOLL

Background Information: TLR4 is a member of Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR4 receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.

Reconstitution Instructions:

NCBI Gene Symbol: TLR4

Gene ID: 7099

NCBI Accession: O00206