TIGAR, human recombinant

TIGAR, human recombinant is available at Gentaur for Next week delivery.

Catalyzes the hydrolysis of fructose-2-6 bisphosphate

Biomolecule/Target: TIGAR

Alternates names: TP53-induced glycolysis and apoptosis regulator (TIGAR)

Synonyms: TP53-induced glycolysis and apoptosis regulator (TIGAR)

Background Information: TIGAR is a p53-inducible enzyme that catalyzes the hydrolysis of fructose-2-6 bisphosphate (F-2-6-BP) to fructose-6-phosphate and inorganic phosphate. F-2-6-BP is a powerful activator of 6-phosphofructose-1 kinase, the rate limiting enzyme of glycolysis. By lowering the intracellular level of F-2-6-BP, TIGAR expression leads to increased glucose processing via the pentose phosphate pathway, the major cellular source for NADPH. Recombinant human TIGAR expressed in E. coli is a 29.9 kDa protein containing 269 amino-acid residues.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

NCBI Gene Symbol: TIGAR

Gene ID: 57103

NCBI Accession: Q9NQ88