TACE (TNF-α converting enzyme), human recombinant

TACE (TNF-α converting enzyme), human recombinant is available at Gentaur for Next week delivery.

Involved in the processing of TNF-α at the surface of cells

Biomolecule/Target:

Alternates names: Disintegrin and metalloproteinase domain-containing protein 17, ADAM 17, Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme

Synonyms: Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme, CD156b

Background Information: TACE (TNF-alpha converting enzyme, ADAM17) is a membrane-bound Metalloprotease from the ADAM (a disintegrin and Metalloprotease) family of proteins. It cleaves 26kDa type II membrane-bound precursor of TNF-a into 17 kDa mature form which is secreted. TACE is also known to process other membrane proteins including TNF receptor, TGF-alpha and amyloid protein precursor. Recombinant active untagged TACE amino acid sequence is from Arg215 to Asn651. The apparent molecular weight is bigger than the calculated MW due to the protein posttranslational modification in eukaryotic system.

Reconstitution Instructions: With sterile deionized water at 0.1µg protein/µl.

NCBI Gene Symbol: ADAM17

Gene ID: 6868

NCBI Accession: P78536