Sirtuin 6, human recombinant

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SKU:
7578-10
$183
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Description

Sirtuin 6, human recombinant is available at Gentaur for Next week delivery.

A NAD-dependent protein deacetylase

Biomolecule/Target: Sirtuin 6

Alternates names: SIRT6, NAD-dependent Deacetylase Sirtuin-6; Mono-ADP-ribosyltransferase Sirtuin 6; SIR2-like Protein 6; SIR2L6

Synonyms: SIRT6, NAD-dependent Deacetylase Sirtuin-6; Mono-ADP-ribosyltransferase Sirtuin 6; SIR2-like Protein 6; SIR2L6

Background Information: Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards 'Lys-9' and 'Lys-56' of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-α.

Reconstitution Instructions: N/A

NCBI Gene Symbol: SIRT6

Gene ID: 51548

NCBI Accession: Q8N6T7

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Additional Information

Size:
10 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
E. coli
Purity by SDS-PAGE:
≥90%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
<0.1 EU/μg by LAL method
Activity (Specifications/test method):
N/A
Biological activity:
N/A
Results:
N/A
Molecular Weight:
~45.0 kDa. Human sirtuin 6 (aa 1-355) is fused at the N-terminus to a His-tag.
Storage Temperature:
-20°C
Shelf Life:
6 months
Concentration:
N/A
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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