sIL-4Rα, Human Recombinant

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SKU:
P1287-3
£135.37
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Description

sIL-4Rα, Human Recombinant is available at Gentaur for Next week delivery.

Plays an important role in regulating the differentiation of naive CD4 T cells and class switching to IgG1 and IgE.

Biomolecule/Target: sIL-4Rα

Alternates names: soluble IL-4 receptor alpha, CD124, IL-4R subunit alpha, IL-4R-alpha, IL-4RA, Soluble IL-4 receptor subunit alpha, Soluble IL-4R-alpha, sIL4Ralpha/prot, IL-4-binding protein, IL4-BP

Synonyms: soluble IL-4 receptor alpha, CD124, IL-4R subunit alpha, IL-4R-alpha, IL-4RA, Soluble IL-4 receptor subunit alpha, Soluble IL-4R-alpha, sIL4Ralpha/prot, IL-4-binding protein, IL4-BP

Background Information: IL-4 can signal through type I and type II receptor complexes, which share a common γ chain (γc). The type I receptor contains in addition to the γ chain an IL-4Rα subunit, whereas the type II receptor contains the IL-13Rα. The secreted extracellular domain of IL-4Rα, called sIL-4Rα, binds IL-4 and antagonizes its activity. It plays an important role in regulating the differentiation of naive CD4 T cells and class switching to IgG1 and IgE. Recombinant human sIL-4Rα is a 209 amino acid protein which corresponds to the entire extracellular domain of IL-4Rα.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Note: Slow to dissolve. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

NCBI Gene Symbol:

Gene ID:

NCBI Accession: P24394

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Additional Information

Size:
3 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
HEK293 cells
Purity by SDS-PAGE:
≥ 98%
Assay:
SDS-PAGE
Endotoxin Level:
<0.1 EU/μg
Biological activity:
The ED50 was determined by its ability to inhibit the IL-4 dependent proliferation of human TF-1 cells is ≤ 5.0 ng/ml (in the presence of 0.5 ng/ml of IL-4), corresponding to a specific activity of ≥ 2 x 10 AA Sequence
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized
Handling:
Centrifuge the vial prior to opening.
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