sCD23, Human Recombinant

sCD23, Human Recombinant is available at Gentaur for Next week delivery.

A low affinity receptor for IgE

Biomolecule/Target: sCD23

Alternates names: CD23 antigen, Fc-epsilon-RII, Lymphocyte IgE receptor, BLAST-2

Synonyms: CD23 antigen, Fc-epsilon-RII, Lymphocyte IgE receptor, BLAST-2

Background Information: CD23, the low affinity receptor for IgE, belongs to the C-type lectin structural family and plays a role in the regulation of IgE synthesis and IgE mediated activities. It is found both as a transmembrane receptor protein and in a soluble form, which is generated by proteolytic cleavage of membrane bound CD23. The predominant soluble form of CD23 (sCD23) consists of 172 amino acids corresponding to the extracellular domain of the full length precursor. sCD23, in addition to binding IgE, also exerts a number of IgE independent activities, such as promoting the activation and differentiation of B-cells and stimulating the release of pro-inflammatory cytokines from monocytes. Recombinant human sCD23 is a 19.2 kDa non-glycosylated protein containing 172 amino-acid residues.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

NCBI Gene Symbol: CD23

Gene ID: 9606

NCBI Accession: Q30218