RAGE, human recombinant

RAGE, human recombinant is available at Gentaur for Next week delivery.

Transmembrane receptor of the immunoglobulin super family

Biomolecule/Target: RAGE

Alternates names: Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products, AGER

Synonyms: Receptor for advanced glycosylation end products

Background Information: Advanced glycosylation end product-specific receptor, also known as receptor for advanced glycosylation end products, AGER and RAGE, belongs to the immunoglobulin superfamily of cell surface molecules. It lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Besides AGEs, AGER is also able to bind other ligands which is thought to result in pro-inflammatory gene activation. It is known that AGER serves as a mediator of both acute and chronic vascular inflammation in certain conditions such as atherosclerosis and in particular as a complication of diabetes. Furthermore, it plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.

Reconstitution Instructions: Dissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100 μg/ml.). After adding 1x PBS, let the tube stand at room temperature for 3 minutes to allow lyophilized protein to dissolve. Mix the solution by inverting the tube 5 times. Centrifuge to pool sample.

NCBI Gene Symbol: AGER

Gene ID: 117

NCBI Accession: Q15109