RAF1, Active

RAF1, Active is available at Gentaur for Next week delivery.

A proto-oncogene

Biomolecule/Target:

Alternates names: RAF, RAF proto-oncogene serine/threonine-protein kinase , Proto-oncogene c-RAF

Synonyms: RAF, RAF proto-oncogene serine/threonine-protein kinase

Background Information: RAF1 is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly (1). The activated RAF1 can phosphorylate and activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration (2).

Reconstitution Instructions: N/A

NCBI Gene Symbol: RAF1

Gene ID: 5894

NCBI Accession: P04049