R-Spondin-1, human recombinant

(No reviews yet) Write a Review
SKU:
7189-50
$719.07
Frequently bought together:

Description

R-Spondin-1, human recombinant is available at Gentaur for Next week delivery.

Stimulates the Wnt/beta-catenin signaling pathway

Biomolecule/Target: R-Spondin-1

Alternates names: Roof plate-specific Spondin, Rspo1

Synonyms: Roof plate-specific Spondin, Rspo1

Background Information: R-Spondin-1 (Rspo-1) belongs to the (Rspo) family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. Rspo-1 is expressed in certain areas of the developing central nervous system, as well as in adrenal glands, ovary, testis, thyroid, and trachea. Rspo can interact with the Frizzled/LRP6 receptor complex in a manner that stimulates the Wnt/beta-catenin signaling pathway. Recombinant human R-Spondin-1 is a 26.7 kDa protein consisting of 243 amino acid residues. Due to glycosylation, R-Spondin-1 migrates at an apparent molecular weight of approximately 40.0 kDa by SDS PAGE analysis under reducing conditions.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

NCBI Gene Symbol: RSPO1

Gene ID: 284654

NCBI Accession: Q2MKA7

View AllClose

Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
CHO Cells
Purity by SDS-PAGE:
≥95%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
HPLC
Endotoxin Level:
< 0.1 ng/μg of protein (<1EU/μg).
Activity (Specifications/test method):
R-spondin-1 enhances BMP-2 mediated differentiation of MC3T3-E1 cells. The expected
View AllClose

0 Reviews

View AllClose