Pro-MMP-8, human

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SKU:
7784-5
$183
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Description

Pro-MMP-8, human is available at Gentaur for Next week delivery.

A Protein involved in breakdown of extracellular matrix

Biomolecule/Target:

Alternates names: Neutrophil collagenase (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL)

Synonyms: Matrix metalloproteinase-13

Background Information: Human neutrophil collagenase (HNC) has been purified from extracts of fresh and outdated buffy coats and from exudates of phorbol myristate acetate-stimulated neutrophils. The MMP-8 present in the starting material can either be latent or active, or have an app. relative molecular mass of 75-kDa and/or 58-kDa. The rather complex pattern of activation of the latent 58-kDa and 75-kDa species by trypsin, organomercurials and oxidants has been investigated. MMP-8 was shown to preferentially hydrolyze type I over type II, and type III collagens in solution and to be a glycoprotein that contains complex N-linked oligosaccharides leading to multiple forms of MMP-8 in SDS-PAGE. The action of endoglycosidase on the latent 58-kDa form produces 42/40-kDa species (Gao et al. 1992, Mallya et al. 1990). This indicates that MMP-8 is an N-linked, complex glycoprotein that appears to be glycosylated at multiple sites.

Reconstitution Instructions: N/A

NCBI Gene Symbol: MMP8

Gene ID: 4317

NCBI Accession: P22894

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Additional Information

Size:
5 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
No
Source:
Human neutrophil granulocytes (Buffy Coat)
Purity by SDS-PAGE:
N/A
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
HPLC
Endotoxin Level:
N/A
Activity (Specifications/test method):
N/A
Biological activity:
N/A
Results:
N/A
Molecular Weight:
40/42 kDa
Storage Temperature:
-80°C
Shelf Life:
12 months
Concentration:
>100 mUnits/mg
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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