Description
PNP, human recombinant is available at Gentaur for Next week delivery.
Catalyzes the reversible phosphorolysis of ribonucleosides and 2'-deoxyribonucleosides
Biomolecule/Target: PNP
Alternates names: Purine nucleoside phosphorylase, NP, Inosine phosphorylase, PRO1837, PUNP
Synonyms: Purine nucleoside phosphorylase, NP, Inosine phosphorylase, PRO1837, PUNP
Background Information: PNP belongs to the PNP/MTAP phosphorylase family of proteins. This protein catalyzes the reversible phosphorolysis of ribonucleosides and 2'-deoxyribonucleosides with specificity for guanine, hypoxanthine and their analogs. PNP deficiency is a rare autosomal recessive genetic disease associated with a severe defect in T-lymphocyte function and neurologic disorder in children, comprising four percent of combined immunodeficiency cases. Recombinant human PNP protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques
Reconstitution Instructions: N/A
NCBI Gene Symbol: PNP
Gene ID: 4860
NCBI Accession: P00491
Additional Information
Size: |
100 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
E. coli. |
Purity by SDS-PAGE: |
≥90% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
N/A |
Endotoxin Level: |
N/A |
Activity (Specifications/test method): |
N/A |
Biological activity: |
Specific activity is > 40,000 pmol/min/µg. One unit will form 1.0 pmole of 7-Methyl-6-thioguanosine to 7-Methyl-6-thioguanine per minute at PH 7.5 at 25ºC |
Results: |
Specific activity is > 40,000 pmol/min/µg |
Molecular Weight: |
34.2 kDa (309 aa, 1-289 aa + His Tag) |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
1 mg/ml |
Appearance: |
Liquid |
Handling: |
Centrifuge the vial prior to opening. |