PIM2, Active

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SKU:
7730-5
$719.07
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Description

PIM2, Active is available at Gentaur for Next week delivery.

A proto-oncogene

Biomolecule/Target:

Alternates names: PIM, Serine/threonine-protein kinase Pim-2

Synonyms: PIM, Serine/threonine-protein kinase Pim-2

Background Information: Baytel et al. identified a deduced 334-amino acid sequence of the clone, which showed 90% identity with the mouse Pim2 protein. Like mouse Pim2, the human protein appears to be a serine threonine kinase. Northern blot analysis detected 2 PIM2 transcripts in all tissues tested, but most abundantly in hematopoietic tissues, spleen, thymus, and peripheral blood leukocytes, as well as in testis, small intestine, and colon. It was also highly expressed in human leukemic and lymphoma cell lines and a colorectal adenocarcinoma cell line. The results suggested a role for PIM2 in proliferating cells as well as during meiosis (1). Yan et al investigated potential functions for the pim family of kinases in factor-dependent murine hematopoietic cells and indicate that pim-2 functions similarly to pim-1 as a pro-survival kinase and suggest that BAD is a legitimate PIM-2 substrate (2). Hammerman et al concluded that the transcriptional induction of Pim-2 initiated a novel NF-kappaB activation pathway that regulates cell survival (3).

Reconstitution Instructions: N/A

NCBI Gene Symbol: PIM2

Gene ID: 11040

NCBI Accession: Q9P1W9

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Additional Information

Size:
5 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Recombinant:
Yes
Source:
Baculovirus (Sf9 insect cells)
Purity by SDS-PAGE:
≥95%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
HPLC
Endotoxin Level:
N/A
Activity (Specifications/test method):
305 nmol phosphate incorporated into the S6K substrate peptide per minute per mg protein at 30°C for 15 minutes using a final concentration of 50 µM ATP (0.83 µCi/assay).
Biological activity:
N/A
Results:
N/A
Molecular Weight:
61.0 kDa
Storage Temperature:
-80°C
Shelf Life:
12 months
Concentration:
5µg/50 µl
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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