NQO1, human recombinant

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SKU:
7571-50
£135.37
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Description

NQO1, human recombinant is available at Gentaur for Next week delivery.

Catalyzes the reduction of highly reactive quinone metabolites and their derivatives

Biomolecule/Target: NQO1

Alternates names: NAD(P)H Dehydrogenase (Quinine) 1 (NQO1); Quinone Reductase 1 (QR1); DT-Diaphorase (DTD); Azoreductase; Phylloquinone Reductase; Menadione Reductase; Dioxin-inducible 1; Disphorase-4 (DIA4); NAD(P)H Quinone Oxireductase; Quinone Oxidoreductase 1

Synonyms: NAD(P)H Dehydrogenase (Quinine) 1 (NQO1); Quinone Reductase 1 (QR1); DT-Diaphorase (DTD); Azoreductase; Phylloquinone Reductase; Menadione Reductase; Dioxin-inducible 1; Disphorase-4 (DIA4); NAD(P)H Quinone Oxireductase; Quinone Oxidoreductase 1

Background Information: NQO1 is a cytosolic antioxidant flavoprotein that catalyzes the reduction of highly reactive quinone metabolites and their derivatives by using NAD (P)H as an electron donor. Thus NQO1 acts as a detoxifying enzyme and is involved in the body’s protection against oxidative stress. NQO1 acts as a protein chaperone, one of its targets being p53. In humans NQO1 is expressed at high levels in adipocytes and its expression levels are positively correlated with adiposity, glucose tolerance, and makers of liver dysfunction. Altered expression of NQO1 is associated with Alzheimer’s disease. NQO1 is abnormally elevated in many types of solid tumors and may represent a useful biomarker of pancreatic cancer.

Reconstitution Instructions: N/A

NCBI Gene Symbol: NQO1

Gene ID: 1728

NCBI Accession: P15559

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
E. coli
Purity by SDS-PAGE:
≥90%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
<0.1 EU/μg by LAL method
Activity (Specifications/test method):
N/A
Biological activity:
N/A
Results:
N/A
Molecular Weight:
~30.0 kDa. Human NQO1 (aa 1-274) is fused at the C-terminus to a His-tag.
Storage Temperature:
-20°C
Shelf Life:
6 months
Concentration:
N/A
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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