Notch-1, mouse recombinant

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SKU:
7530-25
€185
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Description

Notch-1, mouse recombinant is available at Gentaur for Next week delivery.

Protein involved in lateral inhibition in embryogenesis and multiple cellular processes through-out adulthood.

Biomolecule/Target: Notch-1

Alternates names: Neurogenic Locus Notch Homolog Protein 1; Notch A; mT14; p300

Synonyms: Neurogenic Locus Notch Homolog Protein 1; Notch A; mT14; p300

Background Information: Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.

Reconstitution Instructions: Reconstitute with sterile water to 1 mg/ml.

NCBI Gene Symbol: NOTCH1

Gene ID: 18128

NCBI Accession: Q01705

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Additional Information

Size:
25 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Mouse
Recombinant:
Yes
Source:
CHO cells
Purity by SDS-PAGE:
≥95%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
<0.1 EU/μg purified protein
Activity (Specifications/test method):
N/A
Biological activity:
N/A
Results:
N/A
Molecular Weight:
~85.0 kDa. The extracellular domain of mouse Notch-1 (aa 19-488) (12 epidermal growth factor-like (EGF) repeats) is fused at the C-terminus to the Fc portion of human IgG1.
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized
Handling:
Centrifuge the vial prior to opening.
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