NNT-1/BCSF-3, Human Recombinant

NNT-1/BCSF-3, Human Recombinant is available at Gentaur for Next week delivery.

Promotes the survival of chick embryonic motor and sympathetic neurons

Biomolecule/Target: NNT-1/BCSF-3

Alternates names: Novel Neurtrophin-1, NNT-1, B-Cell-Stimulating Factor-3, BSF-3, Cardiotrophin-like cytokine, Cardiotrophin-like cytokine factor 1 (CLCF1), CLCF1, BSF3, CLC, NNT1

Synonyms: Novel Neurtrophin-1, NNT-1, B-Cell-Stimulating Factor-3, BSF-3, Cardiotrophin-like cytokine, Cardiotrophin-like cytokine factor 1 (CLCF1), CLCF1, BSF3, CLC, NNT1

Background Information: NNT-1/BCSF-3 is a neurotrophic factor with B-cell stimulating capabilities. Expressed in lymph nodes and spleen, NNT-1/BCSF-3 binds and activates glycoprotein 130 (gp130) and leukemia inhibitory factor receptor member β (LIFR-β) and induces tyrosine phosphorylation of these receptors. In vitro, it supports the survival of chick embryo motor and sympathetic neurons. In mice, NNT-1/BCSF-3 induces serum amyloid A, causes body weight loss and B cell hyperplasia associated with increased in serum IgG and IgM. Human Recombinant NNT-1/BCSF-3 is a 22.4 kDa protein containing 199 amino acid residues.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

NCBI Gene Symbol: CLCF1

Gene ID: 23529

NCBI Accession: Q9UBD9