Description
NMNAT3, human recombinant is available at Gentaur for Next week delivery.
Catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP.
Biomolecule/Target: NMNAT3
Alternates names: Nicotinamide Mononucleotide Adenylyl-transferase 3; NMN Adenylyltransferase 3; NaMN Adenylyltransferase 3; EC 2.7.7.18; EC 2.7.7.1
Synonyms: Nicotinamide Mononucleotide Adenylyl-transferase 3; NMN Adenylyltransferase 3; NaMN Adenylyltransferase 3; EC 2.7.7.18; EC 2.7.7.1
Background Information: This is the Mitochondrial NMNAT isoform. It catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. It can also use the deamidated form of nicotinic acid mononucleotide (NAMN) as substrate with the same efficiency. It can use tiazofurin monophosphate as substrate. It can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+. For the pyrophosphorolytic activity, mitochondrial NMNAT isoform can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. It fails to cleave phosphorylated dinucleotides NADP+, NADPH and NAADP+. It protects against axonal degeneration following injury.
Reconstitution Instructions: N/A
NCBI Gene Symbol: NMNAT3
Gene ID: 349565
NCBI Accession: Q96T66
Additional Information
Size: |
50 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
E. coli |
Purity by SDS-PAGE: |
≥95% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
N/A |
Endotoxin Level: |
N/A |
Activity (Specifications/test method): |
N/A |
Biological activity: |
≥ 2U/mg protein. One unit is defined as the amount of enzyme that synthesizes 1 µmol of NAD+ per min. |
Results: |
≥ 2U/mg protein. One unit is defined as the amount of enzyme that synthesizes 1 µmol of NAD+ per min. |
Molecular Weight: |
~27.0 kDa (monomer). Human full-length NMNAT3 (aa 1-252) is fused at the N-terminus to a His-tag. |
Storage Temperature: |
-20°C |
Shelf Life: |
6 months |
Concentration: |
1 mg/ml |
Appearance: |
Liquid |
Handling: |
Centrifuge the vial prior to opening. |