MMP-9, Active, Human Recombinant

MMP-9, Active, Human Recombinant is available at Gentaur for Next week delivery.

A Protein involved in breakdown of extracellular matrix

Biomolecule/Target:

Alternates names: Matrix Metalloproteinase-9, Gelatinase B, 92 kDa Type IV Collagenase, MMP9, CLG4B, GELB, MANDP2

Synonyms: Matrix Metalloproteinase-9, Gelatinase B, 92 kDa Type IV Collagenase, MMP9, CLG4B, GELB, MANDP2

Background Information: Matrix metallopeptidase 9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B, is the mostly studied MMP, due to its fundamental role in cancer biology, autoimmune disease, and other conditions. This enzyme degrades various substrates including gelatin, collagen types IV and V, and elastin. MMP-9 is structurally a multi-domain metalloenzyme, composed of a prodomain, a catalytic domain, a gelatin binding domain, a metal-binding domain, and a carboxyl terminal hemopexin like domain. This active human MMP-9 is composed of the catalytic domain, a gelatin binding domain, and a metal-binding domain (AA 107-457). The protein was expressed in E. coli and purified and refolded using proprietary techniques.

Reconstitution Instructions: Reconstitute with pre-chilled 30% Glycerol/H2O solution to 0.1 µg/µl and incubate on ice until it completely dissolves. Aliquot and store the reconstituted MMP-9 at -20°C. Stable for 2 months after reconstitution.

NCBI Gene Symbol: MMP-9

Gene ID: 4319

NCBI Accession: P14780