MERS-CoV Spike S2 Protein

MERS-CoV Spike S2 Protein is available at Gentaur for Next week delivery.

S2 protein enables membrane fusion

Biomolecule/Target:

Alternates names: Middle East respiratory syndrome coronavirus; Human betacoronavirus 2c EMC/2012; Middle East respiratory syndrome-related coronavirus; S glycoprotein; EMC/2012; E2; Peplomer protein; Spike protein S2

Synonyms: Middle East respiratory syndrome coronavirus; Human betacoronavirus 2c EMC/2012; Middle East respiratory syndrome-related coronavirus; S glycoprotein; EMC/2012; E2; Peplomer protein; Spike protein S2

Background Information: MERS-CoV is a coronavirus which causes the Middles East Respiratory Syndrome (MERS). MERS-CoV has four structural proteins, known as the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins. The spike protein is responsible for allowing the virus to attach and fuse with the membrane of a host cell. Spike glycoprotein is cleaved into three chains: S1, S2’ and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for membrane fusion. MERS-CoV S mediates viral attachment and fusion to human cells via human cellular receptor DPP4, also known as CD26. The S protein plays an important role in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

Reconstitution Instructions:

NCBI Gene Symbol:

Gene ID:

NCBI Accession: K0BRG7, AFS88936