MAPKAPK3, Active

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SKU:
7755-5
£135.37
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Description

MAPKAPK3, Active is available at Gentaur for Next week delivery.

Involved in many cellular processes

Biomolecule/Target:

Alternates names: MAPKAPK, mitogen-activated protein kinase-activated protein kinase 3

Synonyms: MAPKAPK, mitogen-activated protein kinase-activated protein kinase 3

Background Information: MAPKAPK3 has a single potential SH3-binding site in the proline-rich N terminus, a putative ATP-binding site, 2 MAP kinase phosphorylation site motifs, and a putative nuclear localization signal. It shares 72% nucleotide and 75% amino acid identity with MAPKAPK2 (1). MAPKAPK3 was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses (2). This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation (3). MAPKAPK3 is uniquely poised to support luteal maturation through the phosphorylation and activation of the nuclear transcription factor CREB (4).

Reconstitution Instructions: N/A

NCBI Gene Symbol: MAPKAPK3

Gene ID: 7867

NCBI Accession: Q16644

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Additional Information

Size:
5 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Recombinant:
Yes
Source:
Baculovirus (Sf9 insect cells)
Purity by SDS-PAGE:
≥90%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
HPLC
Endotoxin Level:
N/A
Activity (Specifications/test method):
636 nmol phosphate incorporated into MBP protein per minute per mg protein at 30°C for 15 minutes using a final concentration of 50 µM ATP (0.83 µCi/assay).
Biological activity:
N/A
Results:
N/A
Molecular Weight:
69.0 kDa
Storage Temperature:
-80°C
Shelf Life:
12 months
Concentration:
5µg/50 µl
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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