Lin28-TAT, Human Recombinant

Lin28-TAT, Human Recombinant is available at Gentaur for Next week delivery.

Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis.

Biomolecule/Target: Lin28-TAT

Alternates names: CSDD1, LIN28A, ZCCHC1, Protein lin-28 homolog A, Zinc finger CCHC domain-containing protein 1

Synonyms: CSDD1, LIN28A, ZCCHC1, Protein lin-28 homolog A, Zinc finger CCHC domain-containing protein 1

Background Information: Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits ZCCHC11/TUT4 uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells.

Reconstitution Instructions: Reconstitute in sterile deionized water to a concentration of 0.1-1.0 mg/ml. Do not vortex. Additional carrier protein (example 0.1% BSA) is recommended for long term storage.

NCBI Gene Symbol: LIN28A

Gene ID: 79727

NCBI Accession: Q9H9Z2