Isocitrate Dehydrogenase 1 R132H mutant, Recombinant Human

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SKU:
P1070-50
$719.07
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Description

Isocitrate Dehydrogenase 1 R132H mutant, Recombinant Human is available at Gentaur for Next week delivery.

Catalyzes the rate-limiting step in Citric acid cycle

Biomolecule/Target:

Alternates names: Isocitrate dehydrogenase [NADP] cytoplasmic, R132H, IDH 1 R132H

Synonyms: Isocitrate dehydrogenase [NADP] cytoplasmic, R132H, IDH 1 R132H

Background Information: Mutations of the cytosolic IDH 1 are a common feature in primary human brain cancers. Arginine 132 (R132) of IDH is highly conserved among different isoforms of IDH and is most commonly mutated to Histidine. Mutation of IDH1 R132H leads to accumulation of R(-)-2-hydroxyglutarate (2HG), which correlates with an increased risk for malignant brain tumors.

Reconstitution Instructions: Reconstitute in deionized water to the final concentration 0.5 mg/ml and incubate the reconstituted protein at 25 °C for 15 minutes.

NCBI Gene Symbol: IDH1

Gene ID: 3417

NCBI Accession: O75874

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
E. Coli
Purity by SDS-PAGE:
≥90%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
N/A
Activity (Specifications/test method):
N/A
Biological activity:
≥ 300 mU/mg, in which one unit is the amount of enzyme that will convert 1.0 µmole of NADPH to NADP+ per minute at pH 7.4 at 25 ̊C.
Results:
≥ 300 mU/mg
Molecular Weight:
50.9 kDa
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized
Handling:
Centrifuge the vial prior to opening.
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