IL17 A/F, Mouse Recombinant

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SKU:
7586-50
$183
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Description

IL17 A/F, Mouse Recombinant is available at Gentaur for Next week delivery.

Induces the production of a variety of chemokines

Biomolecule/Target: IL17 A/F

Alternates names: Interleukin 17 A/F, IL-17A, IL-17F, Interleukin 17A, Interleukin 17F

Synonyms: Interleukin 17 A/F, IL-17A, IL-17F, Interleukin 17A, Interleukin 17F

Background Information: Interleukin-17AF (IL-17AF) is a member of the IL-17 family of proteins produced by a subset of T cells, called Th17, following stimulation with IL-23. Since IL-17AF is thought to signal through the IL-17R receptor, its biological function is similar to that of IL-17A in that it induces the production of a variety of chemokines, in addition to airway neutrophilia. In regard to these functions, IL-17AF has less activity than the IL-17A homodimer but, greater activity than the IL-17F homodimer. Human and rat IL-17AF both show activity on mouse cells. Recombinant mouse IL-17AF is a non-glycosylated, disulfide-linked heterodimer. It is comprised of one monomeric subunit each of IL-17A and IL-17F, having a total of 271 amino acids and a molecular weight of 30.7 kDa.

Reconstitution Instructions: Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/mL, which can be further diluted into other aqueous solutions.

NCBI Gene Symbol: IL17 A/F

Gene ID: 16171/257630

NCBI Accession: Q62386/Q7TN17

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Mouse
Recombinant:
Yes
Source:
E. coli
Purity by SDS-PAGE:
≥98%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
Measured by kinetic LAL analysis and is typically ≤ 1 EU/μg protein
Activity (Specifications/test method):
The activity determined by the dose-dependent induction of IL-6 production in cultured mouse NIH 3T3 fibroblasts, is typically 75-325 ng/mL.
Biological activity:
The activity determined by the dose-dependent induction of IL-6 production in cultured mouse NIH 3T3 fibroblasts, is typically 75-325 ng/mL.
Results:
N/A
Molecular Weight:
30.7 kDa.
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized
Handling:
Centrifuge the vial prior to opening.
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