IL-36γ, Human Recombinant

IL-36γ, Human Recombinant is available at Gentaur for Next week delivery.

An agonist of NF-kappaB

Biomolecule/Target: IL-36γ

Alternates names: IL-1F, IL-1ε (epsilon), IL-1F9, IL-1H1

Synonyms: IL-1F, IL-1ε (epsilon), IL-1F9, IL-1H1

Background Information: The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36 α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36γ is highly expressed in psoriatic plaques and in tissues containing epithelial cells. IL-36γ signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36γ also functions as an agonist of NF-kappaB, and can stimulate the inflammatory response in bronchial epithelial cells. Recombinant human IL-36γ is a 17.0 kDa protein containing 152 amino acid residues.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

NCBI Gene Symbol: IL36G

Gene ID: 56300

NCBI Accession: Q9NZH8