IGF-BP5, human recombinant

IGF-BP5, human recombinant is available at Gentaur for Next week delivery.

A protein which binds and prolongs the half-life of the IGFs

Biomolecule/Target:

Alternates names: Insulin-like Growth Factor-Binding Protein5

Synonyms: Insulin-like Growth Factor-Binding Protein5

Background Information: Human IGF-BP5 is a 28.6 kDa cysteine-rich secreted protein produced by Vascular smooth muscle cells. It is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGF-I on smooth muscle cells, fibroblasts or osteoblasts. Studies show that IGF-BP5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGF-BP5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole body growth inhibition, and retarded muscle development. Recombinant human IGF-BP5 is a 28.6 kDa protein consisting of 253 amino acid residues.

Reconstitution Instructions: Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or –20°C for future use.

NCBI Gene Symbol: IBP5

Gene ID: 3488

NCBI Accession: P24593