IGF-BP3, human recombinant

IGF-BP3, human recombinant is available at Gentaur for Next week delivery.

A protein which binds and prolongs the half-life of the IGFs

Biomolecule/Target:

Alternates names: Insulin-like Growth Factor-Binding Protein 3, Growth-hormone-dependant binding protein

Synonyms: Insulin-like Growth Factor-Binding Protein 3, Growth-hormone-dependant binding protein

Background Information: Human IGF-BP3, also known as growth-hormone-dependant binding protein, is a 28.9 kDa cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals. In addition to its ability to modulate the activity of IGF-I and IGF-2, IGF-BP3 also exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF. Recombinant human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues.

Reconstitution Instructions: Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or –20°C for future use.

NCBI Gene Symbol: IBP3

Gene ID: 3486

NCBI Accession: P17936