Human Stathmin 1 / STMN1 Protein

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SKU:
7881-20
£135.37
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Description

Human Stathmin 1 / STMN1 Protein is available at Gentaur for Next week delivery.

An important regulatory protein of microtubule dynamics.

Biomolecule/Target: Stathmin 1 / STMN1

Alternates names: STMN1, Stathmin, C1orf215, LAP18, OP18

Synonyms: STMN1, Stathmin, C1orf215, LAP18, OP18

Background Information: Stathmin (STMN1), a member of the stathmin family, is also known as Leukemia-associated phosphoprotein p18, Oncoprotein 18 (Op18), Phosphoprotein p19 (pp19), Protein Pr22 and pp17, which contains one SLD (stathmin-like) domain. The function of STMN1 as an important regulatory protein of microtubule dynamics has been well-characterized. Stathmin (STMN1) interacts with two molecules of dimeric α,β-tubulin to form a tight ternary complex called the T2S complex.One mole of STMN1 binds to two moles of tubulin dimers through the stathmin-like domain (SLD).When STMN1 sequesters tubulin into the T2S complex, tubulin becomes non-polymerizable. Without tubulin polymerization, there is no microtubule assembly.STMN1 also promotes microtubule disassembly by acting directly on the microtubule ends.

Reconstitution Instructions: Reconstitute in sterile PBS, pH7.4 to a stock solution of 400 µg/mL. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% (W/V) HSA or BSA) is recommended for further dilution and long term storage.

NCBI Gene Symbol: STMN1

Gene ID: 3925

NCBI Accession: P16949

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Additional Information

Size:
20 µg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
E. coli
Purity by SDS-PAGE:
>92%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
<1 EU/μg by LAL method
Activity (Specifications/test method):
N/A
Biological activity:
N/A
Results:
N/A
Molecular Weight:
18.1 kDa
Storage Temperature:
+4°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Dry powder
Handling:
Centrifuge the vial prior to opening.
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