Human Stathmin 1 / STMN1 Protein

Human Stathmin 1 / STMN1 Protein is available at Gentaur for Next week delivery.

An important regulatory protein of microtubule dynamics.

Biomolecule/Target: Stathmin 1 / STMN1

Alternates names: STMN1, Stathmin, C1orf215, LAP18, OP18

Synonyms: STMN1, Stathmin, C1orf215, LAP18, OP18

Background Information: Stathmin (STMN1), a member of the stathmin family, is also known as Leukemia-associated phosphoprotein p18, Oncoprotein 18 (Op18), Phosphoprotein p19 (pp19), Protein Pr22 and pp17, which contains one SLD (stathmin-like) domain. The function of STMN1 as an important regulatory protein of microtubule dynamics has been well-characterized. Stathmin (STMN1) interacts with two molecules of dimeric α,β-tubulin to form a tight ternary complex called the T2S complex.One mole of STMN1 binds to two moles of tubulin dimers through the stathmin-like domain (SLD).When STMN1 sequesters tubulin into the T2S complex, tubulin becomes non-polymerizable. Without tubulin polymerization, there is no microtubule assembly.STMN1 also promotes microtubule disassembly by acting directly on the microtubule ends.

Reconstitution Instructions: Reconstitute in sterile PBS, pH7.4 to a stock solution of 400 µg/mL. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% (W/V) HSA or BSA) is recommended for further dilution and long term storage.

NCBI Gene Symbol: STMN1

Gene ID: 3925

NCBI Accession: P16949