Human Recombinant Ubiquitin-K29

(No reviews yet) Write a Review
SKU:
6398-500
$183
Frequently bought together:

Description

Human Recombinant Ubiquitin-K29 is available at Gentaur for Next week delivery.

Serves as a substrate for K29 polyubiquitination

Biomolecule/Target:

Alternates names:

Synonyms: Human Recombinant Ubiquitin-K29

Background Information: Ubiquitin is a small polypeptide that can be conjugated via its C-terminus to amine groups of lysine residue on target proteins. This conjunction is referred to as monoubiquitylation. Additional ubiquitin moieties can be subsequently conjugated to this initial ubiquitin, utilizing any one of the seven lysine residues on the surface of ubiquitin. The formation of these ubiquitin chains is referred to as polyubiquitylation. This tag-free recombinant form of human ubiquitin is engineered to have all available lysines mutated to arginines, except at position 29. This molecule, therefore, can only form polyubiquitin chains of K29 linkage type. Covalent attachment of ubiquitin to other proteins serves various functions, but its major role is to target cellular proteins for destruction. Cellular components that activate, transfer, remove, or simply recognize ubiquitin number in the hundreds, perhaps even in the thousands. In light of this complexity the ubiquitin pathway is ideal for a systems biology approach. Ubiquitin plays a very important role in regulated non-lysosomal ATP dependent protein degradation. The Ub-proteasome proteolytic pathway, which is a complex process, is implicated to be of great importance for regulating numerous cellular processes.

Reconstitution Instructions: N/A

NCBI Gene Symbol: RPS27A

Gene ID: 6233

NCBI Accession: P62979

View AllClose

Additional Information

Size:
500 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
E. Coli
Purity by SDS-PAGE:
≥95%
Assay:
RP-HPLC
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
N/A
Activity (Specifications/test method):
N/A
Biological activity:
N/A
Results:
N/A
Molecular Weight:
8.732 kDa
Storage Temperature:
-80°C
Shelf Life:
12 months
Concentration:
4 mg/ml
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
View AllClose

0 Reviews

View AllClose