Human Recombinant PAI-1

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SKU:
6377-100
€185
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Description

Human Recombinant PAI-1 is available at Gentaur for Next week delivery.

Activator of plasminogen and fibrinolysis

Biomolecule/Target:

Alternates names: Plasminogen activator inhibitor-1, SERPINE1, PAI, PAI1, PLANH1.

Synonyms: Human Recombinant PAI-1

Background Information: Plasminogen activator inhibitor-1 is the principal inhibitor of tissue plasminogen activator (tPA) and Urokinase (uPA), the activators of plasminogen and hence fibrinolysis (the physiological breakdown of blood clots). It is a serine protease inhibitor (serpin) protein (SERPINE1). The other PAI, plasminogen activator inhibitor-2 (PAI-2) is secreted by the placenta and only present in significant amounts during pregnancy. In addition, protease nexin acts as an inhibitor of tPA and urokinase. SERPINE1, however, is the main inhibitor of the plasminogen activators.

Reconstitution Instructions: N/A

NCBI Gene Symbol: SERPINE1

Gene ID: 5054

NCBI Accession: P05121

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Additional Information

Size:
100 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
E. Coli
Purity by SDS-PAGE:
≥95%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
N/A
Activity (Specifications/test method):
N/A
Biological activity:
Specific activity, the IC50 value is < 56 nM. Measured by its ability to inhibit uPA cleavage of the substrate Z-GGR-AMC.
Results:
<56 nM
Molecular Weight:
45 kDa (400 aa, 24-402 aa + NT His-Tag)
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
1 mg/ml
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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