Human Recombinant MDH1

Human Recombinant MDH1 is available at Gentaur for Next week delivery.

Involved in oxidation of malate to OAA

Biomolecule/Target:

Alternates names: Malate dehydrogenase cytoplasmic, MDH-s, MDHA, MOR2

Synonyms: Human Recombinant MDH1

Background Information: Malate Dehydrogenase, Cytoplasmic (MDH1) is an enzyme which belongs to the MDH Type 2 sub-family of LDH/MDH superfamily. MDH1 is involved in the Citric Acid Cycle that catalyzes the conversion of Malate into Oxaloacetate (using NAD+) and vice versa. MDH1 should not be confused with Malic Enzyme, which catalyzes the conversion of Malate to Pyruvate, producing NADPH. MDH1 also participates in Gluconeogenesis, the synthesis of Glucose from smaller molecules. Pyruvate in the mitochondria is acted upon by Pyruvate Carboxylase to form Oxaloacetate, a Citric Acid Cycle intermediate. In order to transport the Oxaloacetate out of the Mitochondria, Malate Dehydrogenase reduces it to Malate, and it then traverses the inner mitochondrial membrane. Once in the cytosol, the Malate is oxidized back to Oxaloacetate by MDH1. Finally, Phosphoenol-Pyruvate Carboxy Kinase (PEPCK) converts Oxaloacetate to Phosphoenol Pyruvate.

Reconstitution Instructions: N/A

NCBI Gene Symbol: MDH1

Gene ID: 4190

NCBI Accession: P40925