Human Recombinant FKBP4

(No reviews yet) Write a Review
SKU:
6343-100
$719.07
Frequently bought together:

Description

Human Recombinant FKBP4 is available at Gentaur for Next week delivery.

An immunophilin family protein functioning as a protein folding chaperone

Biomolecule/Target:

Alternates names: FK506 binding protein 6, FKBP52, FKBP59, HBI, Hsp56, p52, PPIase

Synonyms: Human Recombinant FKBP4

Background Information: FKBP4 is part of the immunophilin protein family, which takes part in immunoregulation and necessary cellular processes concerning protein folding and trafficking. It is a cis-trans prolyl isomerase that connects to the immunosuppressants FK506 and rapamycin. FKBP4 has high structural and functional similarity to FKBP1A, although, FKBP4 does not have immunosuppressant activity when complexed with FK506. FKBP4 interacts with interferon regulatory factor-4 and is involved in immunoregulatory gene expression in B and T lymphocytes. FKBP4 is known to connect with phytanoyl-CoA alpha-hydroxylase. FKBP4 associates with HSP90 & HSP70 thus takes part in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. FKBP4 highly associates with adeno-associated virus type 2 vectors (AAV) resulting in a considerable increase in AAV-mediated transgene expression in human cell lines. FKBP4 is involved in the optimal use of AAV vectors in human gene therapy.

Reconstitution Instructions: N/A

NCBI Gene Symbol: FKBP4

Gene ID: 2288

NCBI Accession: Q02790

View AllClose

Additional Information

Size:
100 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
E. Coli
Purity by SDS-PAGE:
≥90%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
< 1.0 EU per 1 μg of protein (determined by LAL method).
Activity (Specifications/test method):
N/A
Biological activity:
Specific activity is > 300 nmoles/min/mg.
Molecular Weight:
53.9 kDa
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
1 mg/ml
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
View AllClose

0 Reviews

View AllClose